The Breakthrough Junior Challenge is an annual global competition for students to inspire creative thinking about science. Students ages 13 to 18 from countries across the globe are invited to create and submit original videos (3:00 minutes in length maximum) that bring to life a concept or theory in the life sciences, physics or mathematics. This year, there is an additional COVID-19 category. The submissions are judged on the student’s ability to communicate complex scientific ideas in engaging, illuminating, and imaginative ways. The Challenge is organized by the Breakthrough Prize Foundation. The Breakthrough Prize was created to honor important advancements in the categories of Fundamental Physics, Life Sciences and Mathematics. The Breakthrough Prizes are sponsored by Sergey Brin, Priscilla Chan and Mark Zuckerberg, Pony Ma, Yuri and Julia Milner, and Anne Wojcicki. The Breakthrough Prize aims to celebrate the best scientific work and inspire the next generation of scientists.