Wellcome exists to improve health by helping great ideas to thrive. They support researchers, we take on big health challenges, we campaign for better science, and we help everyone get involved with science and health research. Wellcome is a politically and financially independent foundation. Their founder, Sir Henry Wellcome, was a medical entrepreneur, collector and philanthropist. How they work today reflects the breadth of his interests, and his conviction that health can be improved when research generates, tests and investigates new ideas. Their governance is based on an updated version of Henry’s will. Today, they have a £25.9 billion investment portfolio which funds all the work they do. In the next five years, they plan to spend around £5 billion helping people across the world explore great ideas.